{"key":"a04b678a-09ee-4d09-9d3f-537d152b00f4","installationKey":"7092f0d0-91a2-4734-8dc7-3e688df82d04","publishingOrganizationKey":"1d594620-2249-4532-ad9e-1b06f3a988d2","doi":"10.15468/qevfuh","external":false,"numConstituents":0,"type":"CHECKLIST","title":"PHYTOCHEMISTRY AND PHARMACOLOGY OF ETHIOPIAN TRADITIONAL ANTIVIRAL PLANTS","description":"\n            This dataset represents studies on the in vitro antiviral activities of plants reported for their traditional uses in treating viral diseases in Ethiopia.  A total of fifty-eight species were best represented. Of the 58 medicinal plant extracts tested, 10(17%) showed very good antiviral activity against viruses, with half maximal inhibitory concentration (IC50) value below 11µg/ml. \n        ","language":"eng","citation":{"text":"Fekadu M (2025). PHYTOCHEMISTRY AND PHARMACOLOGY OF ETHIOPIAN TRADITIONAL ANTIVIRAL PLANTS. Addis Ababa University. Checklist dataset https://doi.org/10.15468/qevfuh accessed via GBIF.org on 2026-10-12.","citationProvidedBySource":false},"contactsCitation":[{"key":6831743,"abbreviatedName":"Fekadu M","firstName":"Mekbib","lastName":"Fekadu","roles":["ORIGINATOR"],"userId":[]}],"lockedForAutoUpdate":false,"createdBy":"1d594620-2249-4532-ad9e-1b06f3a988d2","modifiedBy":"crawler.gbif.org","created":"2025-12-31T11:44:30.348+00:00","modified":"2025-12-31T11:45:30.992+00:00","contacts":[{"key":6831743,"type":"ORIGINATOR","primary":true,"userId":[],"firstName":"Mekbib","lastName":"Fekadu","position":[],"email":["mekbib_fekadu@yahoo.com"],"phone":["+251923026813"],"homepage":[],"organization":"Addis Ababa University","address":[],"city":"Addis Ababa","country":"ET","postalCode":"3434","createdBy":"crawler.gbif.org","modifiedBy":"crawler.gbif.org","created":"2025-12-31T11:45:30.971+00:00","modified":"2025-12-31T11:45:30.971+00:00"},{"key":6831744,"type":"ADMINISTRATIVE_POINT_OF_CONTACT","primary":true,"userId":[],"firstName":"Hanny Lidetu","lastName":"Solomon","position":["Data Steward"],"email":["hanny.lidetu@aau.edu.et"],"phone":["+251991433277"],"homepage":[],"organization":"Addis Ababa University","address":["Addis Ababa, Ethiopia"],"city":"Addis Ababa","country":"ET","postalCode":"3434","createdBy":"crawler.gbif.org","modifiedBy":"crawler.gbif.org","created":"2025-12-31T11:45:30.974+00:00","modified":"2025-12-31T11:45:30.974+00:00"}],"endpoints":[{"key":1230333,"type":"DWC_ARCHIVE","url":"https://cloud.gbif.org/africa/archive.do?r=checklist","createdBy":"1d594620-2249-4532-ad9e-1b06f3a988d2","modifiedBy":"1d594620-2249-4532-ad9e-1b06f3a988d2","created":"2025-12-31T11:44:30.482+00:00","modified":"2025-12-31T11:44:30.482+00:00","machineTags":[]},{"key":1230332,"type":"EML","url":"https://cloud.gbif.org/africa/eml.do?r=checklist","createdBy":"1d594620-2249-4532-ad9e-1b06f3a988d2","modifiedBy":"1d594620-2249-4532-ad9e-1b06f3a988d2","created":"2025-12-31T11:44:30.445+00:00","modified":"2025-12-31T11:44:30.445+00:00","machineTags":[]}],"machineTags":[{"key":33143047,"namespace":"crawler.gbif.org","name":"crawl_attempt","value":"36","createdBy":"crawler.gbif.org","created":"2026-10-12T02:32:39.816+00:00"}],"tags":[],"identifiers":[{"key":461566,"type":"CLB_DATASET_KEY","identifier":"313604","createdBy":"clb-bot","created":"2025-12-31T11:50:02.164+00:00","primary":false},{"key":461565,"type":"URL","identifier":"https://cloud.gbif.org/africa/resource?r=checklist","createdBy":"crawler.gbif.org","created":"2025-12-31T11:45:30.978+00:00","primary":false},{"key":461564,"type":"UUID","identifier":"f3ebe890-d447-486c-8844-5801f71e8f6d","createdBy":"crawler.gbif.org","created":"2025-12-31T11:45:30.976+00:00","primary":false}],"comments":[],"bibliographicCitations":[{"text":"Asres, K., Bucar, F., Kartnig, T., Witvrouw, M., Pannecouque, C., & Clercq, E. D. (2001). Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanically selected Ethiopian medicinal plants. Phytotherapy Research, 8, 62–69.","citationProvidedBySource":false},{"text":"Bagla, V. P., McGaw, L. J., & Eloff, J. N. (2012). The antiviral activity of six south African plants traditionally used against infections in ethnoveterinary medicine. Veterinary Microbiology, 155, 198–206. https://doi.org/10.1016/j.vetmic.2011.09.015.","citationProvidedBySource":false},{"text":"Cos, P., Hermans, N., De, B. T., Apers, S., Sindambiwe, J. B., Witvrouw, M., De, C. E., Vanden, B. D., Pieters, L., & Vlietinck, A. J. (2002). Antiviral FEKADU ET AL. 935 10991573, 2024, 2, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/ptr.8084 by EBMG ACCESS - ETHIOPIA, Wiley Online Library on [29/06/2025]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1). Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 9(1), 62–68. https://doi.org/10.1078/ 0944-7113-00083.","citationProvidedBySource":false},{"text":"Javed, T., Ashfaq, U. A., Riaz, S., Rehman, S., & Riazuddin, S. (2011). In-vitro antiviral activity of Solanum nigrum against hepatitis C virus. Virology Journal, 8(1), 26. https://doi.org/10.1186/1743-422X-8-26.","citationProvidedBySource":false},{"text":"Jo, M., Nakamura, N., Kakiuchi, N., Komatsu, K., Qui, M., Shimotohno, K., Shimotohno, K., & Hattori, M. (2006). Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase. Journal of Natural Medicines, 60, 2017–2224. https://doi.org/10.1007/s11418-006-0041-7.","citationProvidedBySource":false},{"text":"Romeilah, R., Fayed, S., & Mahmoud, G. (2010). Chemical compositions, antiviral and antioxidant activities of seven essential oils. Journal of Applied Sciences Research, 6, 50–62.","citationProvidedBySource":false},{"text":"Seo, D. J., & Choi, C. (2017). Inhibitory mechanism of five natural flavonoids against murine norovirus. Phytomedicine, 30, 59–66. https://doi.org/10.1016/j.phymed.2017.04.011","citationProvidedBySource":false}],"curatorialUnits":[],"taxonomicCoverages":[],"geographicCoverages":[{"description":"Ethiopia","boundingBox":{"minLatitude":-90.0,"maxLatitude":90.0,"minLongitude":-180.0,"maxLongitude":180.0,"globalCoverage":true}}],"temporalCoverages":[],"keywordCollections":[{"thesaurus":"GBIF Dataset Type Vocabulary: http://rs.gbif.org/vocabulary/gbif/dataset_type_2015-07-10.xml","keywords":["Checklist"]}],"project":{"title":"Building capacity within biodiversity data between Ethiopia and GBIF nodes in Sweden and Finland","identifier":"CESP2024-013","contacts":[{"type":"POINT_OF_CONTACT","primary":false,"userId":[],"firstName":"Veronika","lastName":"Johansson","position":[],"email":[],"phone":[],"homepage":[],"address":[]}],"awards":[],"relatedProjects":[],"abstract":"Biodiversity is crucial for maintaining a healthy environment, ensuring food security, and building resilience, especially in developing countries such as Ethiopia. Rich in biodiversity and traditional farming systems, Ethiopia hosts the Eastern Afromontane biodiversity hotspot as well as the Horn of Africa biodiversity hotspot, which are critical for the Arabica coffee wild gene pool, but one of the least developed globally. Conserving biodiversity in Ethiopia requires robust evidence, skills, and policies, and quality data production and effective mobilization to data aggregators like GBIF are essential.\n\nThe biodiversity data in Ethiopia is available in fragmented forms across various institutions, limiting access, especially for policymakers and practitioners. This bottleneck is largely due to the need for skills in developing and managing databases and making data available in an integrated manner at national, regional, and global scales. In addition, there is a shortage of analytical skills in producing quality scientific data and knowledge.\n\nThis project aims to extend the work initiated in 2017 by the EU-funded GBIF Biodiversity Information for Development project BIDERSE and to address challenges by providing capacity-building training and knowledge transfer, enabling stakeholders to mobilize, manage, and use data according to global best practices. The key stakeholders identified for establishing a national biodiversity platform will act as a basis for this initiative."},"samplingDescription":{"studyExtent":"This study has also attempted to review published studies on the in vitro antiviral activities of plants reported for their traditional uses in treating viral diseases in Ethiopia.","sampling":"In these studies, the aerial part, leaf, stem, root, bark, seed, and fruit of the plant have been used to prepare extracts using solvents such as dichloromethane, petroleum ether, ethanol, methanol, and water.","methodSteps":["Studies commonly used cellular assays such as MTT (Asres et al., 2001), cytopathogenic effect (Romeilah et al., 2010), and plaque reduction (Seo & Choi, 2017); and molecular assays such as RNA-dependent RNA polymerase inhibition (Jo et al., 2006), enzyme-linked immunosorbent assay (ELISA), and quantitative RT-PCR assay (Javed et al., 2011) to check the antiviral activities of the plant extracts against different viruses. Viruses such as human immunodeficiency viruses (types 1 and 2), herpes simplex viruses (types 1 and 2), coxsackievirus B, human influenza virus A (H1N1), avian influenza virus A (H5N1), and hepatitis C and B were cultured with different doses of extracts on different cell lines (Bagla et al., 2012). Frequently reported cell lines compatible with the growth of the viruses were Human T-lymphocytic MT-4 cells, Vero cells, and human cervix carcinoma\n(HeLa) cell lines, and Madin–Darby canine kidney cell lines (Bagla et al., 2012; Cos et al., 2002)."]},"countryCoverage":[],"collections":[],"dataDescriptions":[{"name":"The potential of Ethiopian medicinal plants to treat emergent viral diseases","url":"https://10.1002/ptr.8084","format":"Review article"}],"dataLanguage":"eng","pubDate":"2025-08-19T00:00:00.000+00:00","maintenanceUpdateFrequency":"UNKNOWN","maintenanceDescription":"","license":"http://creativecommons.org/licenses/by/4.0/legalcode","dwca":{"coreType":"http://rs.tdwg.org/dwc/terms/Taxon","extensions":["http://rs.iobis.org/obis/terms/ExtendedMeasurementOrFact"],"modified":"2025-12-31T11:45:30.926+00:00"},"approximateCounts":{"occurrenceCount":0,"nameUsageCount":96}}